Empowering Older Antibiotics
نویسنده
چکیده
Avycaz combines an older cephalosporin antibiotic, ceftazidime, and the β-lactamase inhibitor avibactam. Ceftazidime targets penicillin-binding proteins (PBPs) in the bacterial periplasm that are required for cell wall synthesis. Avibactam blocks β-lactamases (β-L) in the periplasm, which would otherwise inactivate the antibiotics resulting in drug resistance.
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ورودعنوان ژورنال:
- Cell
دوره 167 شماره
صفحات -
تاریخ انتشار 2016